Correspondingly, evidence of CD8+ T-cell infiltration was also identified in the precursor lesions, lending credibility to the idea that these mutations occur early in the transition from normal to cancer cell, and that the neoantigens resulting from POLE-driven genome instability recruit immune cells that predicate the high amount of immune cell infiltration observed in resected tumors of both endometrium and colon or rectum. Here, POLE is linked to cancer.