ERBB2 and breast cancer: As shown in Additional file 9: Figure S7A–F, the prognostic epigenetic signature serves as a promising biomarker for predicting the survival of breast cancer in different subgroups, including Luminal A type (p = 0.03), Luminal B type (p = 0.026), HER2-enriched (p = 0.012) and triple negative (p = 0.004), stage I-II (p < 0.001), stage III-IV (p < 0.001) patients, respectively.