Cellular markers of the tumour biology such as IHC positivity for estrogene receptor (ER), progesteron recepetor (PR), epidermal growth factor receptor 2 (HER-2), cytokeratin 5/6, epidermal growth factor receptor 1 (EGFR) and for cell proliferation (Ki67) are currently the gold standard for therapy stratification, but require considerable laboratory work and are prone to subjective bias. This evidence concerns the gene MKI67 and neoplasm.