HMGB1 and hepatocellular carcinoma: For example, miR‐506 could inhibit the proliferation of hepatocellular carcinoma cells by targeting YAP mRNA 3'UTR region.67 Another example is that miR‐325 could suppress the cell invasion and proliferation of hepatocellular carcinoma through regulating HMGB1 gene.68 Therefore, 49 of the top 50 candidate miRNAs for hepatocellular cancer were supported by either database or literature evidence.