Moreover, In a murine model, the mast cells may induce IL-6, IL-8, and RANTES after the release of TNF-α and IL-1β.[15] Consequently, the increase of inflammatory cytokines induced by autoantibodies may drive mast cells to the bladder lamina propria of detrusor muscle, which is related to the pathogenesis of BPS/IC.[16]. Here, IL1B is linked to Bartsocas-Papas syndrome 1.