This finding agrees with a different study which concluded that the transcriptome of lung cancer lesions from the same patients cluster together with global unsupervised clustering analysis.33 The RNA‐seq data was concordant with PD‐L1, CD8 and Ki67 protein expression (Figure 4C‐E), underscoring the high quality of the transcriptomic and protein data. The gene discussed is CD274; the disease is lung cancer.