Specifically, the injury‐induced TLR2 was completely reduced in galectin‐3 KO mice poststroke both in vitro and in vivo.106 Galectin‐3 ablation KO leads to a reduction in IGF‐1, which is a microglia‐regulated inflammatory protein, as presented in a mouse model of stroke.106 Taken together, these data suggest that the innate immune system is involved in the sexual dimorphism that exists between males and females after stroke. Here, IGF1 is linked to stroke disorder.