CX3CL1 and obesity due to melanocortin 4 receptor deficiency: This was shown in the hypothalamic microglial activated CX3CL1‐CXCLR1 pathway in a mouse model of obesity.39 Dorfman et al found that increased CXCLR1, which is associated with energy expenditure, allowed for females to be more resistant to obesity.39 This therefore supports the idea that differences in microglial function exist between males and females.