IGF1 and Stroke: Specifically, the injury‐induced TLR2 was completely reduced in galectin‐3 KO mice poststroke both in vitro and in vivo.106 Galectin‐3 ablation KO leads to a reduction in IGF‐1, which is a microglia‐regulated inflammatory protein, as presented in a mouse model of stroke.106 Taken together, these data suggest that the innate immune system is involved in the sexual dimorphism that exists between males and females after stroke.