RNF5 and cystic fibrosis: Interestingly, RNF5 was recently described as a potential novel drug target in CF, because, when RNF5 activity is decreased, the mutant CFTR protein becomes stabilized and its function as a cAMP-dependent chloride channel in the lung epithelium is partially rescued (Sondo et al., 2018; Tomati et al., 2015).