Our group has long focused on studying the anticancer effects of ARS compounds on different types of cancer, including hepatocellular carcinoma, breast cancer and ovarian cancer.6, 7, 8, 9, 10 Several other studies have also shown that ARSs promote cell apoptosis and inhibit invasion in glioma,33 and the mechanisms involve AKT signalling34 and ROS‐β‐catenin signalling.35 However, the roles of ARS compounds in cancer metabolism have never been elucidated. This evidence concerns the gene AKT1 and breast carcinoma.