Previous studies have shown that IR is capable of activating the proliferation of glioma cells that express stem cell markers, such as STAT3, slug, and MSI1, and these results are consistent with the role of CSCs in radioresistance.5, 21, 22 Our previous study revealed that radioresistant CSCs have an activated DNA repair ability, and homologous recombination is a major mechanism underlying the observed radioresistance.5, 21, 22 Moreover, glioblastoma stem‐like cells that repair DSBs are correlated with enhanced activation of the DDR. This evidence concerns the gene STAT3 and central nervous system cancer.