LAMC2 and polycystic kidney disease: Abnormal expression of laminin5 contributes to the aberrant proliferation of cyst epithelial cells in polycystic kidney disease.37 A cell signalling pathway involving laminin5 can regulate epithelial cell proliferation.38 Furthermore, in mice, disrupted laminin staining at the basement membrane on the aboral side of the tooth leads to the process of dental lamina loss.2 We showed that LamC2 expression was decreased after the cap stage in the developing tooth germ in mice; however, Laminin5 expression was maintained in the successional dental lamina in the teeth of juvenile geckos.