Furthermore, the results of immunofluorescence histochemical staining further indicated that ATP1A3 and AQP4 colocalized in normal brain tissues (left panel), and ATP1A3 was decreased while AQP4 was increased significantly in GBM tissues (right panel) compared with normal tissues (Figure 3D), suggesting that the expression of ATP1A3 might be negatively correlated with AQP4 expression. Here, AQP4 is linked to glioblastoma.