Intriguingly, a recent study indicated that TMZ had therapeutic potential for suppressing malignant glioma by inhibiting AQP4 expression through activation of the p38 signal transduction pathway,21 indicating that screening for specific small‐molecule inhibitors of the AQP4‐MAPK pathway may contribute to the design of novel mechanism‐based therapies for GBM. This evidence concerns the gene AQP4 and malignant glioma.