In addition, TCGA data analysis indicated that the expression of AQP4 in tumour tissue samples was significantly higher than that in paracancerous tissues (P < .05) (Figure 4C), and the overall survival of GBM patients with lower expression of AQP4 was significantly better than that of patients with relatively higher expression (P < .01) (Figure 4D). Here, AQP4 is linked to glioblastoma.