Currently, an increasing number of studies have indicated the important roles of AQP4 in the malignant growth of gliomas.18 The expression of AQP4 was shown to be increased in glioma, while AQP4 inhibition could significantly hinder glioma growth.19, 20 However, the mechanisms of AQP4 function in glioma still require more systematic and comprehensive research. Here, AQP4 is linked to central nervous system cancer.