In addition, AQP4 has long been studied in various brain pathological conditions, and AQP4 knockout could play important roles in neurodegenerative diseases.39 Interestingly, AQP4 deficiency was previously found to cause the dysregulation of Na+/K+‐ATPase.40 The current study comprehensively and systematically explored the therapeutic potential of AQP4 in GBM, and for the first time, we found that AQP4 suppression could significantly promote TMZ sensitivity. Here, AQP4 is linked to glioblastoma.