According to the literature, leiomyomas have different genetic drivers, that the most common are rearrangements in HMGA2 (high mobility group AT‐hook 2), inactivation of FH (fumarate hydratase), and mutations in the MED12 (mediator complex subunit 12).6 Among these, somatic mutations in the MED12 exon 2 have a higher frequency in diverse populations.7, 8, 9 Mehine et al6 suggested that each genetic driver results in a different expression pattern in ULMs. Here, MED12 is linked to leiomyoma.