The prescription rates of RAS inhibitors (82.3% vs 59.9%), beta blockers (80.6% vs 66.8%) and mineralocorticoid receptor antagonist (MRA) (54.8% vs 33.1%) in HFrEF patients were much higher in the CHECK-HF registry compared to the CHAMP-HF registry (Fig. 4a). The gene discussed is NR3C2; the disease is hydrops fetalis.