Other genes like the WNT4, ESR2 and SF-1 have a necessary role for ovarian and testicular development function70–72 as demonstrated by the fact that genetic variants in these genes cause gonadal dysgenesis in 46,XY individuals70,73,74, with ovarian failure in women and ovotesticular DSD42,70,74. The gene discussed is ESR2; the disease is ovarian dysfunction.