The top-ranked SNP, rs7593613, was located in the regulatory subunit of the protein phosphatase B gene (PPP3R1), also known as calcineurin B. This marker was in high linkage disequilibrium (LD) with 2 other SNPs located on the same locus and showing significant associations with AD (rs28694054, p = 3.4e−03; rs11692815, p = 4.3e−03). This evidence concerns the gene PPP3R1 and Alzheimer disease.