The melanomas with ARID2 mutation were significantly associated with a higher age at diagnosis, both when the age was dichotomously categorized according to the mean age (χ2 = 5.07, p = 0.024) and when age was evaluated as a continuous predictor (logistic regression, Wald statistics = 4.03, p = 0.044). The gene discussed is ARID2; the disease is melanoma.