Several studies have also analyzed a spectrum of somatic mutations in distinct melanoma subtypes and identified the key CM drivers that comprised mutations in BRAF, RAS (mainly NRAS, but mutations in HRAS and KRAS are responsible for <1%), NF1, TP53, CDKN2A, PTEN, IDH1, ARID2, RAC1, RB1, and PPP6C2–7. This evidence concerns the gene NRAS and melanoma.