By contrast, there are few reports on ARHGEF3 and HSPA13 in chickens, most of the articles about the ARHGEF3 are related to disease in human, such as acute myeloid leukemias (D’Amato et al. 2015), nasopharyngeal carcinoma cell pathogenesis (Liu et al. 2016) and platelet function (Zou et al. 2017), as for HSPA13, few studies in NCBI database. This evidence concerns the gene HSPA13 and acute myeloid leukemia.