GRIN2A and Parkinson disease: In an animal model of PD, partial lesions of dopaminergic fibers had no effect on GluN2B levels, but resulted in an increase of GluN2A levels, while full lesions reduced GluN2B levels without altering GluN2A (Picconi et al., 2004, Gardoni et al., 2006; Paillé et al., 2010).