For example, circulating concentration of monocyte chemoattractant protein-1 (MCP-1/CCL2) has been shown to correlate with the degree of interstitial macrophage infiltration in human DKD while, experimentally, inhibition of MCP-1 in models of diabetes mellitus (DM) ameliorates renal injury [11–13]. The gene discussed is CCL2; the disease is diabetes mellitus.