Unexpectedly, the C4F6-reactive misfolded SOD1 was also detected in some PD cases (5 out of 12 cases: C-24, C-28, C-29, C-30, and C-33) as well as two PSP cases (C-22 and C-25) albeit with significantly smaller amounts (Fig. 4). The gene discussed is SOD1; the disease is supranuclear palsy, progressive, 1.