More precisely, as shown in Figs. 5 and 8a, the ALS cases with a significantly high percentage (> 60%) of C4F6-reactive SOD1 (ALS8, 9, 11, 12, 13) exhibited almost no enzymatic activity of SOD1, while distinct activity bands were observed in the cases with a moderate percentage (< 60%) of C4F6-reactive SOD1 (ALS1, 2, 3, 4, 5, 6). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.