Even without the data on ALS10, statistically significant differences still existed in the apparent amounts of apoSOD/EDI-reactive SOD1 between sALS and non-ALS cases (P values with Mann-Whitney U-test are as follows; 1.1 × 10− 8 and 3.6 × 10− 10 in apoSOD and EDI, respectively). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.