SOD1 and amyotrophic lateral sclerosis: We found that the absorption of misfolded SOD1 with C4F6 significantly ameliorated the toxicity of the CSF samples from the ALS cases as well as the PDSOD1 and PSPSOD1 cases (P < 0.01 in ALS w/ C4F6 vs. ALS and also in PDSOD1/PSPSOD1 w/ C4F6 vs. PDSOD1/PSPSOD1; Fig. 9a, black filled bars vs. white bars).