To get insights into the misfolded conformation(s) of wild-type SOD1 in CSF of the ALS cases, several other polyclonal antibodies that recognize distinct epitopes only available in misfolded SOD1 were used as capture antibodies in the sandwich ELISA; apoSOD [36], EDI, UβB, 24–39 [27], and SOD1int [35] (Table 3). Here, SOD1 is linked to amyotrophic lateral sclerosis.