When re-examined, our sandwich ELISA with C4F6 showed that those PD and PSP cases with the C4F6-reactive misfolded SOD1 (called PDSOD1 and PSPSOD1 cases, respectively) were characterized by slightly higher apparent amounts of C4F6-reactive SOD1 than those in the cases without it (shown as black filled circles in Fig. 3a). The gene discussed is SOD1; the disease is Parkinson disease.