Through Kaplan-Meier survival analysis and the log-rank statistical test for single-factor analysis of survival, we found that SIRT4 expression in the peritumour tissues was positively correlated with the survival of HCC patients, and there was no correlation between the expression of SIRT4 in HCC tumour tissues and pathological characteristics (P > 0.05). This evidence concerns the gene SIRT4 and neoplasm.