Furthermore, as shown in Fig. 1e and f, Kaplan-Meier analysis and log-rank statistical test showed that SIRT4 levels in HCC peritumour tissues were positively associated with the survival of HCC patients (42.9% vs 15.0%, p = 0.015), while the expression of SIRT4 in tumour tissues was not associated with the prognosis of HCC patients (p = 0.133). The gene discussed is SIRT4; the disease is hepatocellular carcinoma.