PLOD1 and polycystic ovary syndrome: To study the relationship between the PCOS and sympathetic innervations, the most commonly used PCOS model is generated by a single injection of EV in prepubertal rats, which results in a polycystic ovary morphology, irregular estrous cycles [30, 31], alterations in basal and pulsatile luteinizing hormone (LH) concentrations and follicle stimulating hormone (FSH) concentrations and an increased androgen response to human chorionic gonadotropin stimulation [32].