In a similar manner, Bachawal et al. concluded that γ-tocotrienol in combination to erlotinib or gefitinib but not trastuzumab, induces apoptosis in +SA mammary tumor cells, as annexin V staining demonstrated an increase in the percentage of cells in the annexin V+/PI− quadrant indicating that treated cells are in the early apoptosis stage [20]. Here, ANXA5 is linked to breast cancer.