Figure 2B shows that in normal cells there are balanced levels of the two NF-YA isoforms; the “short” (NF-YAs) is substantially increased (p value 10−23), and NF-YAl decreased (p value 10−7), in tumor samples. As a result, a robust change in the ratio of isoforms levels is produced (Figure 2C). As for NF-YC, the predominant 37 kD and 50 kD isoforms are concomitantly increased (p value 10−8/9, Figure 2D). Here, NFYC is linked to neoplasm.