NFYA and neoplasm: In addition to finding an abundance of CCAAT in promoters of “cancer” genes as in other tumor types, three new findings are reported: (i) overexpression of NF-YA, notably the “short” isoform, correlating with known proliferation markers; (ii) identification of a distinct cohort of tumors with higher NF-YAl levels and a CCAAT-less pro-migration signature; (iii) negative clinical outcome of tumors with global increase of NF-YA levels as well as an opposite spectra, with low, and high, NF-YAs/NF-YAl isoforms ratios.