NPPB and heart failure: The studies leading up to the takeoff of BNP include the PRIDE (N-Terminal Pro-BNP Investigation of Dyspnea in the Emergency Department), ADHERE (Acute Decompensated Heart Failure National Registry), PROTECT (Use of NT-proBNP Testing to Guide Heart Failure Therapy in the Outpatient Setting), HOPE (Heart Outcomes Prevention Evaluation) studies, and more [15,54,55].