Concordantly, Mishra and colleagues described the downregulation of miR-21 in AR-silenced prostate cancer cell lines (22Rv1 and MDA-PCA-2b), resulting in the increased expression of the miR-21 target gene TGFBR2, as well as the formation of a positive AR-miR-21 feedback loop in prostate epithelial cells [71]. Here, AR is linked to Familial prostate cancer.