Different forms of the anti-CD147 HAb18 were developed, a chimeric antibody, cHAb18, containing variable heavy and light chains of the HAb18 antibody and constant regions of human IgG1γ1, modulated cytoskeleton rearrangement via FAK-PI3K-AKT signaling pathway and inhibited invasion and metastasis in hepatocellular carcinoma [74]. This evidence concerns the gene BSG and hepatocellular carcinoma.