CD147 expression increased chemotherapeutic drug resistance (Doxorubicin, BCNU, Taxol and Vincristine) via hyaluronan [90] and CD44 interaction, including receptor tyrosine kinase, ABS transporter and MCTs activities facilitating drug efflux with resistance to cisplatin and methotrexate in head and neck cancer [91], to cisplatin in lung cancer [92], and to vincristine in lymphoma [93]. This evidence concerns the gene BSG and lymphoma.