BSG and neoplasm: A glycoprotein belonging to the immunoglobulin family and enriched on the surface of various types of tumor and stromal cells, including epithelial cells and fibroblasts [13], CD147 was initially named TCSF (tumor cell-derived collagenase stimulatory factor) and renamed Extracellular Matrix MetalloPRoteinase INducer (EMMPRIN) based on its matrix metalloproteinase (MMP) inducer function [14].