FOXO3 and malignant colon neoplasm: Indeed, Gao et al. [54] revealed that overexpression of miR-155 in colon cancer tissues and human colon cancer cell lines (HT29 and SW620) was associated with decreased levels of FOXO3a. In addition, their study showed that miR-155 may not only promote colon cancer growth but also increase colon cancer chemo-resistance to cisplatin through inhibiting FOXO3a expression.