Uric acid-lowering drugs, such as xanthine oxidase (XOD) inhibitors, uricosuric agents, and anti-inflammatory drugs, are commonly applied in the clinic for gout treatment, although long-term use of those drugs may cause some side effects, such as bone marrow suppression, gastrointestinal irritation, as well as renal toxicity [22]. The gene discussed is XDH; the disease is gout.