GRN and colorectal carcinoma: Based on software prediction and in vitro evidence, it is found that 1) H19 was positively correlated with the pathogenesis of EMT of CRC; 2) H19 competitively sponged miR-29-3b; and 3) H19 negatively regulated miR-29-3b abundance and abolished its suppressive effect on PGRN and Wnt signaling in CRC cells.