Likewise, supplementary studies showed that the RUX2 level was reduced in PVT1-knockdown CRC cell lines, but was induced in miR-30d-5p-knockdown CRC cells, suggesting that PVT1 promoted CRC tumorigenesis partly via this PVT1/miR-30d-5p/RUX2 ceRNA network. This evidence concerns the gene PVT1 and colorectal carcinoma.