ROR1 and colorectal carcinoma: Furthermore, they discovered that atractylenolide II, a natural product extracted from the dried rhizome of Atractylodes macrocephala, successfully enhanced the sensitivity of CRC cells to several first-line chemo drugs, such as 5-fluorouracil (5-FU), doxorubicin (DOX), and cisplatin, by disturbing the XIST/miR-30-5p/ROR1 ceRNA network [112].