The non-dipping pattern is associated with high levels of molecules related to endothelial dysfunction, platelet activation, altered haemostasis and atherosclerosis, such as von Willebrand factor, soluble intercellular adhesion molecule-1, soluble CD40 ligand, D-dimer and plasminogen activator inhibitor-1, all of which contribute to the link between non-dipping pattern and, atherosclerosis and cardiovascular disease [33]. This evidence concerns the gene SERPINE1 and endothelial dysfunction.