Downregulating miR-506 increases the methylation level of MEG3 promoter and inhibits MEG3 expression via the miR-506/SP3/SP1/DNMT1/MEG3 axis in human BC cell lines, resulting in attenuation of metastasis of MCF-7 and MDA-MB-231 cells [111]. This evidence concerns the gene DNMT1 and breast cancer.