ES1 controls the expression of stemness transcription factors in BC cells by regulating the OCT4/SOX2/miR-302 axis [135]; lncRNA-Hh directly targets GAS1 to increase the SOX2 and OCT4 expression, thus promoting the CSCs-like characteristics of Twist-driven EMT cells and Twist-positive BC cells [136]. The gene discussed is POU5F1; the disease is breast cancer.