SMPD1 and arthrogryposis multiplex congenita: In the current study, we tried to investigate whether the increased lysosomal ceramide in SMCs contributes to arterial plasticity by measuring PWV as an index of arterial stiffness.66 We found that SMC‐specific overexpression of Smpd1 significantly increased PWV suggesting that increased lysosomal ceramide due to overexpression of Smpd1 in SMCs contributed to the arterial stiffness during the development of AMC.