In this context, study in ApoE−/− mice and rabbits fed a Western diet reported that inhibition of glycosphingolipid synthesis can prevent the development of atherosclerosis and lower arterial stiffness independent of blood pressure.30 Hence, these studies provide evidence that sphingolipid biosynthesis pathway could be a target for the prevention of arterial stiffness during AMC. The gene discussed is APOE; the disease is atherosclerosis.