Multivariable Cox analysis revealed that MELD-XI score remained an independent predictor of MACE (HR 1.36, 95% CI: 1.17–1.58, P<0.001) even after adjustment of sex, NYHA functional class, eGFR, ALT, SVEF<50%, and the presence of valvular disease and pulmonary hypertension (Table 4). The gene discussed is GPT; the disease is pulmonary arterial hypertension.