KLK3 and Familial prostate cancer: Another study integrated PSAD and the percentage free PSA as their best model (AUC = 0.824) for the probability of detecting prostate cancer in all patients; and the AUC for PSA, percentages of free PSA and PSAD were 0.662, 0.676 and 0.786 respectively.[24] To validate the utility of their model, the best model was applied to an independent cohort of 88 patients.