Definitive diagnosis of prostate cancer depends on histopathological verification of adenocarcinoma in a prostate biopsy that may lead to complications such as infection, bleeding and anxiety.[3] Therefore, it is inappropriate to use a prostate biopsy to perform routine active surveillance on asymptomatic people with elevated serum levels of PSA.[2] Reducing the complications of biopsies requires careful selection of patients who are likely to benefit. Here, KLK3 is linked to Familial prostate cancer.