When we chose the best cut-off values of PSA, PSADTZ, PSADPZ (29.165, 0.705 and 0.975, respectively) for predicting PCa, the sensitivities were 48.9%, 78.3% and 48.4%, respectively and the specificities were 91.5%, 81.4% and 89.8%, respectively. This evidence concerns the gene KLK3 and posterior cortical atrophy.