For example, a study of the utility of PSAD and PSA of 659 patients demonstrated that the AUC of PSAD (0.73) is higher than that of PSA (0.61) for diagnosing PCa.[7] A study of 172 patients found that the AUC of PSA significantly increases from 0.683 to 0.806 using PSAD.[12] However, a study of 109 patients with clinically localized prostate cancer found that PSAD fails to outperform PSA for preoperative prediction of prostate cancer.[20]. The gene discussed is KLK3; the disease is Familial prostate cancer.