As described by the International Society of Urological Pathology 2014 grade, patients diagnosed with PCa are stratified using the combination of serum PSA level, Gleason score and clinical staging (cTNM).[2] Risk stratification can help clinicians select treatment strategies such as curative or deferred treatment and predict the outcomes of patients with different levels of risk. This evidence concerns the gene KLK3 and posterior cortical atrophy.