Therefore, the imaging of insulinoma using radionuclide-labeled GLP-1RA has high sensitivity for insulinoma diagnosis, and the specific binding of GLP-1RA to GLP-1R leads to a significant advantage in insulinoma localization, showing promise for use in preoperative and intraoperative localization of insulinoma, as well as its postoperative follow-up. This evidence concerns the gene GLP1R and pancreatic insulinoma.