However, the dynamic change analysis of EMT markers showed that expression of CDH1 was sustained downregulated during ccRCC progression, while the expressions of N-cadherin, VIM and fibronectin were upregulated consistently (Figure 3F), suggesting that the EMT was activated during both tumorigenesis and ccRCC progression. The gene discussed is CDH1; the disease is nonpapillary renal cell carcinoma.