PDCD1 and metabolic syndrome: Thus if PPAR‐γ can directly affect PD‐1 expression, antagonists of PPAR‐γ might be useful in directing antitumor immune responses where PD‐1 interactions with its ligands play a role in dampening immune responses to tumors.14 Therefore, the interplay between PPAR‐γ and PD‐1 in inflammation relating to cancer and metabolic syndromes is an area that should be further explored.