TRIM72 and metabolic syndrome: However, it has been shown that serum MG53 levels in mice with metabolic syndrome induced by a 6‐month high‐fat diet were significantly reduced.19 S‐nitrosylation of MG53 at C144 (cysteine 144) prevented oxidation‐induced degradation of MG53 following oxidative insult, therefore enhancing cardiomyocyte survival.20 In the present study, we tested the hypothesis that the limited protective effect of MG53 on BMSCs against ox‐LDL was due to ox‐LDL‐induced reduction of MG53.