It has been shown that mice with metabolic syndrome induced by 6‐month high‐fat diet (HFD) feeding exhibited a significant increase in serum lipid levels and a significant reduction in circulating MG53 level without change in MG53 expression within skeletal and cardiac muscles.19 In the present study, we also observed that serum MG53 level was significantly decreased in hyperlipidemic LDLR−/− mice (Figure 2C). Here, LDLR is linked to metabolic syndrome.