One of the important components in blood in hyperlipidemic state is ox‐LDL which is considered as a critical contributor to the development of cardiovascular diseases associated with hyperlipidemia (like atherosclerosis).57 In the present study, we demonstrated that treatment of mice with ox‐LDL significantly decreased serum MG53 level without change in MG53 clearance from circulation (Figure 2B and Figure 3B). The gene discussed is TRIM72; the disease is cardiovascular disorder.