It is known that ischaemia/reperfusion or hypoxia/oxidative stress leads to down‐regulation of MG53 in rodent cardiomyocytes.17 Hypercholesterolaemia could block sevoflurane‐induced cardioprotection against ischaemia‐reperfusion injury by alteration of MG53‐mediated pathway.18 Little is known on the metabolism of MG53 in vivo. This evidence concerns the gene TRIM72 and Hypercholesterolemia.