MG53 (also known as TRIM72) is an important membrane‐repairing protein that is produced in striated muscle cells and present in circulation.13 Systemic delivery of MG53 or muscle‐specific overexpression of human MG53 gene enhanced membrane repair and improved muscle and heart functions in a hamster model of muscular dystrophies and congestive heart failure. Here, TRIM72 is linked to congestive heart failure.