Regarding the CSF TDP‐43, CSF NfL, and plasma NfL markers that showed significant elevation in the ALS compared with control groups for both discovery and validation cohorts, we calculated composite parameters of the products of CSF NfL × CSF TDP‐43, of CSF NfL × plasma NfL, and of plasma NfL × CSF TDP‐43 (Fig. 5). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.