Elevated levels of NfL in cerebrospinal fluid (CSF) and plasma/serum have been reported in patients with ALS compared with controls; moreover, they were associated with poor outcomes.1, 2 TAR DNA‐binding protein 43 (TDP‐43) positive inclusions are found in approximately 97% of patients with ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.