Some previous studies suggest that DNA hypermethylation was associated with decreased PPP2R2B expression in breast cancer,30 nasopharyngeal carcinoma cells31 and glioma.32 However, in this study, we observed that the methylation of some CpG sites in two gene body regions of PPP2R2B showed at least moderate positive correlations with PPP2R2B expression. Here, PPP2R2B is linked to nasopharyngeal carcinoma.