Interestingly, we found that SIRT3 siRNA suppressed SIRT3 expression (compared with PDGF‐BB+ celastrol group) without causing significant changes in AMPK phosphorylation and PGC‐1α expression (Figure 9D‐F), suggesting that SIRT3 acts as the down‐stream target of the AMPK‐PGC‐1α signalling in liver fibrosis. Here, PPARGC1A is linked to Hepatic fibrosis.