SIRT3 and Hepatic fibrosis: AMPK has been proved involved in the pathophysiology of liver fibrosis,22 and up‐regulation of AMPK phosphorylation facilitated to the attenuation of liver fibrosis.23 Interestingly, SIRT3 has been reported as a downstream effector of AMPK in several disease models, and activation of AMPK‐SIRT3 signalling contributes to the improvement of mitochondrial function, thus alleviating the progress of diseases.24, 25However, in liver fibrosis, whether celastrol regulate AMPK‐SIRT3 signalling remains poorly understood.