Interestingly, previous studies have shown that celastrol exerted antioxidant effects on skeletal muscle of diabetic rats partly by regulating AMPK‐SIRT3 signalling.48 Consistent with the previous study, under pathological conditions of liver fibrosis, inhibition of AMPK evidently decreased SIRT3 expression and reduced inflammatory inhibition effect of celastrol. The gene discussed is SIRT3; the disease is Hepatic fibrosis.