KCNK18 and migraine disorder: A frameshift mutation, F139WfsX24 in KCNK18 was originally identified in one migraine proband, as part of a larger study investigating the role of brain-expressed ion channel genes in paroxysmal neurological disorders, wherein 150 ion channel genes were sequenced in 110 unrelated migraine subjects (Lafreniere et al., 2010; Lafreniere and Rouleau, 2012).