KCNK18 and gestational trophoblastic neoplasm: We used TRESK knockout mice, in which the majority of the Kcnk18 coding region has been removed (Valenzuela et al., 2003), in order to mimic the complete loss of function conferred by the F139WfsX24 mutation in an in vivo context and to assess the contribution of TRESK to hypersensitivity following chronic GTN.