FGF2 and neoplasm: Besides, PDGF, TGF- β, and FGF-2, together with vascular endothelia growth factor (VEGFR) secreted by fibroblasts and tumor associated macrophages, promote the angiogenesis, lymphangiogenesis, and lymphovascular invasion (Shimada et al., 2017; Van den Eynden et al., 2007).