For example, miR-127-5p can suppress the expression of a tumor suppressor gene (Wang et al., 2011a), miR-136-5p can regulate the expression of CLDN15 (Yurikova et al., 2019), ENAH genes are involved in tumor invasion (Forse et al., 2015; Takehara et al., 2009), and miR-432-3p can affect the gene IL2RB involved in the development of breast cancer (García-Tuñón et al., 2004). The gene discussed is CLDN15; the disease is breast cancer.