In this regard, previous studies, including on the present cohort, have demonstrated that obesity is associated with an increased risk of mismatch repair proficient/microsatellite stable (pMMR/MSS) tumors in both sexes,25,26 whereas another study found a link of obesity and risk of tumors displaying dMMR/MSI tumors only in women .27 Although no association was found between obesity and MSI in a previous study on the present cohort,26 immune infiltration and PD-L1 expression on immune cells have been found to be significantly higher in dMMR tumors,9–11 which is in line with the expected.28 The gene discussed is CD274; the disease is obesity due to melanocortin 4 receptor deficiency.