As the hitherto first study to investigate the impact of obesity on the expression of PD-L1 in CRC, the results demonstrated that several anthropometric factors were associated with risk tumors with of low immune cell-specific PD-L1 expression in men, but with risk of tumors with high immune cell-specific PD-L1 expression in women. The gene discussed is CD274; the disease is obesity due to melanocortin 4 receptor deficiency.