While it is plausible that ANGPTL8 affects beta cells exposed to STZ differently, the utility of ANGPTL8 in treating T1D is limited considering that it did not reduce blood glucose levels or increase insulin levels in either diabetic NOD nor non-diabetic NOD mice (Figure 3(f) and Figure 3(g)). This evidence concerns the gene ANGPTL8 and type 1 diabetes mellitus.