Upon binding to its ligand, the extracellular matrix (ECM) component hyaluronic acid (HA), CD44 plays a key role in various physiological functions by activating different signal transduction pathways leading to cell proliferation, adhesion, migration, angiogenesis and inflammation [1–3], but also in pathophysiologic processes, such as self-renewal, tumor initiation, epithelial mesenchymal transition, metastasis and chemoresistance [4, 5]. Here, CD44 is linked to neoplasm.