Based on the recently described immune cell infiltration and marker analysis [34], an almost statistically significant (p = 0.057) correlation of CD44s expression with PD-L1 (B7-H1) was found in the MM samples analyzed, while partially statistically significant inverse correlation between CD44s protein levels and infiltrating immune effector cells, like CD4+ cells (p = 0.18), CD8+ cells (p = 0.03), and CD68+ M1 macrophages (p = 0.1) was observed. This evidence concerns the gene CD8A and Miyoshi myopathy.