TNF and neoplasm: There are multiple sources of such inflammatory factors: tumor cells, activated immune cells, adipocytes and myocytes, which promote the release of tumorkines, adipokines, myokines, and other inflammatory mediators such as IL-6, TNF-α, IL-1, NFҡB, MCP-1, and other factors involved in tumor growth, angiogenesis and apoptosis process as Fas-associated death domain protein (FADD) [1, 11].