In conclusion, we detected increased levels of ANGPTL-4 in both plasma and tumor tissue from patients with cancer cachexia, and a positive correlation and association were found between ANGPTL-4 and proinflammatory factors such as IL-1β content in tumor and mesenteric adipose tissue and, suggesting that the intensification of the proinflammatory environment could contribute to cancer cachexia development. The gene discussed is IL1B; the disease is neoplasm.