Moreover, loss of RIC8A exhibited no effect on the EGFR TKI sensitivity in EGFR wild-type (EGFR-WT) NSCLC cell lines (A549, NCI-1299 and NCI-H460) or normal human bronchial epithelial cell line BEAS-2B (Figure 3—figure supplement 2A–P). Here, EGFR is linked to non-small cell lung carcinoma.