EGFR and non-small cell lung carcinoma: Several studies have previously employed loss- or gain-of-function screens to profile genetic interactions with mutant EGFR in NSCLC cells to look for synthetic lethality (Bivona et al., 2011; de Bruin et al., 2014; Sharifnia et al., 2014; Lantermann et al., 2015; Liao et al., 2017).