A less stringent threshold (RSA ≤ −3 and Q3 z-score ≥1) expanded the list to 171 genes (Supplementary file 1 and 2), including negative regulators of YAP signaling such as NF2/Merlin and SAV1, further warranting the importance of YAP signaling in mediating EGFR TKI resistance in lung cancer. This evidence concerns the gene YAP1 and lung carcinoma.