FGFR1 and YAP1, two known mediators of EGFR TKI resistance in EGFR-mutant NSCLC (Ware et al., 2013; Hsu et al., 2016; Chaib et al., 2017; Ghiso et al., 2017), were among these hits. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.