Mapping the 35-gene set on the STRING protein-protein interaction network and the Reactome database generated clusters consisting of heparan sulfate metabolism, GPCR/G-protein signaling, Hippo-YAP signaling pathway, as well as components of the SAGA/transcriptional complex (Figure 1G and Figure 1—figure supplement 1F), providing potential synthetic lethal partners with EGFR TKI in EGFR-mutant NSCLC. This evidence concerns the gene YAP1 and non-small cell lung carcinoma.